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Electro-chemical coupling in the voltage-dependent phosphatase Ci-VSP

In the voltage sensing phosphatase, Ci-VSP, a voltage sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo assay, we find that the inter-domain linker that connects the VSD to the PD is e...

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Detalles Bibliográficos
Autores principales: Kohout, Susy C., Bell, Sarah C., Liu, Lijun, Xu, Qiang, Minor, Daniel L., Isacoff, Ehud Y.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857593/
https://www.ncbi.nlm.nih.gov/pubmed/20364128
http://dx.doi.org/10.1038/nchembio.349