Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

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Detalles Bibliográficos
Autores principales: Matveeva, Olga V., Kang, Yibin, Spiridonov, Alexey N., Sætrom, Pål, Nemtsov, Vladimir A., Ogurtsov, Aleksey Y., Nechipurenko, Yury D., Shabalina, Svetlana A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857877/
https://www.ncbi.nlm.nih.gov/pubmed/20422034
http://dx.doi.org/10.1371/journal.pone.0010180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857877/
https://www.ncbi.nlm.nih.gov/pubmed/20422034
http://dx.doi.org/10.1371/journal.pone.0010180

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