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Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857877/ https://www.ncbi.nlm.nih.gov/pubmed/20422034 http://dx.doi.org/10.1371/journal.pone.0010180 |