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Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI

During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-induced changes in basal fu...

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Detalles Bibliográficos
Autores principales: Brickman, Adam M., Small, Scott A., Fleisher, Adam
Formato: Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857999/
https://www.ncbi.nlm.nih.gov/pubmed/19847048
http://dx.doi.org/10.3233/BEN-2009-0240
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author Brickman, Adam M.
Small, Scott A.
Fleisher, Adam
author_facet Brickman, Adam M.
Small, Scott A.
Fleisher, Adam
author_sort Brickman, Adam M.
collection PubMed
description During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-induced changes in basal function, or by measuring stimulus-evoked responses on top of basal changes. Functional magnetic resonance imaging (fMRI) is sensitive to both basal changes and evoked-responses, and there are therefore two experimental approaches in which fMRI can be used to pinpoint synaptic loss in AD. In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy.
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spelling pubmed-28579992010-04-21 Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI Brickman, Adam M. Small, Scott A. Fleisher, Adam Behav Neurol Research Article During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-induced changes in basal function, or by measuring stimulus-evoked responses on top of basal changes. Functional magnetic resonance imaging (fMRI) is sensitive to both basal changes and evoked-responses, and there are therefore two experimental approaches in which fMRI can be used to pinpoint synaptic loss in AD. In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy. IOS Press 2009 2009-10-21 /pmc/articles/PMC2857999/ /pubmed/19847048 http://dx.doi.org/10.3233/BEN-2009-0240 Text en Copyright © 2009 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Brickman, Adam M.
Small, Scott A.
Fleisher, Adam
Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title_full Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title_fullStr Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title_full_unstemmed Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title_short Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI
title_sort pinpointing synaptic loss caused by alzheimer’s disease with fmri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857999/
https://www.ncbi.nlm.nih.gov/pubmed/19847048
http://dx.doi.org/10.3233/BEN-2009-0240
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