Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency

BACKGROUND: Neurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1. Haploinsufficiency of NF1 fosters a permissive tumorigenic environment through changes in signalling between cells, however the intracel...

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Detalles Bibliográficos
Autores principales: Pemov, Alexander, Park, Caroline, Reilly, Karlyne M, Stewart, Douglas R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858150/
https://www.ncbi.nlm.nih.gov/pubmed/20307317
http://dx.doi.org/10.1186/1471-2164-11-194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858150/
https://www.ncbi.nlm.nih.gov/pubmed/20307317
http://dx.doi.org/10.1186/1471-2164-11-194

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