Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina

Functional inactivation of the Retinoblastoma (pRB) pathway is an early and obligatory event in tumorigenesis. The importance of pRB is usually explained by its ability to promote cell cycle exit. Here, we demonstrate that, independently of cell cycle exit control, in cooperation with the Hippo tumo...

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Detalles Bibliográficos
Autores principales: Nicolay, Brandon N., Bayarmagnai, Battuya, Moon, Nam Sung, Benevolenskaya, Elizaveta V., Frolov, Maxim V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858677/
https://www.ncbi.nlm.nih.gov/pubmed/20421993
http://dx.doi.org/10.1371/journal.pgen.1000918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858677/
https://www.ncbi.nlm.nih.gov/pubmed/20421993
http://dx.doi.org/10.1371/journal.pgen.1000918

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