Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein concentrations1–7. In mammalian cells, protein levels also vary8–10 and individual cells differ widely in responsiveness to uniform physiological stimuli11–15. In the case of apoptosis mediated by TRAIL (TN...

Descripción completa

Detalles Bibliográficos
Autores principales: Spencer, Sabrina L., Gaudet, Suzanne, Albeck, John G., Burke, John M., Sorger, Peter K.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858974/
https://www.ncbi.nlm.nih.gov/pubmed/19363473
http://dx.doi.org/10.1038/nature08012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858974/
https://www.ncbi.nlm.nih.gov/pubmed/19363473
http://dx.doi.org/10.1038/nature08012

Ejemplares similares