Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs

BACKGROUND: Microtubule drugs are effective anti-cancer agents, primarily due to their ability to induce mitotic arrest and subsequent cell death. However, some cancer cells are intrinsically resistant or acquire a resistance. Lack of apoptosis following mitotic arrest is thought to contribute to dr...

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Detalles Bibliográficos
Autores principales: Jo, Hakryul, Loison, Fabien, Hattori, Hidenori, Silberstein, Leslie E., Yu, Hongtao, Luo, Hongbo R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859055/
https://www.ncbi.nlm.nih.gov/pubmed/20428237
http://dx.doi.org/10.1371/journal.pone.0010318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859055/
https://www.ncbi.nlm.nih.gov/pubmed/20428237
http://dx.doi.org/10.1371/journal.pone.0010318

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