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The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A
BACKGROUND: Amifostine (WR-2721, delivered as Ethyol(®)) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without reducing their efficacy on tumour cells. Its mechanism of action is attribute...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859403/ https://www.ncbi.nlm.nih.gov/pubmed/20334641 http://dx.doi.org/10.1186/1741-7015-8-19 |