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Conformational Preferences of a 14-Residue Fibrillogenic Peptide from Acetylcholinesterase
[Image: see text] A 14-residue fragment from near the C-terminus of the enzyme acetylcholinesterase (AChE) is believed to have a neurotoxic/neurotrophic effect acting via an unknown pathway. While the peptide is α-helical in the full-length enzyme, the structure and association mechanism of the frag...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860372/ https://www.ncbi.nlm.nih.gov/pubmed/20356043 http://dx.doi.org/10.1021/bi1001807 |