Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound

Tumor differentiation enhances morphologic and microvascular heterogeneity fostering hypoxia that retards intratumoral drug delivery, distribution, and compromise therapeutic efficacy. In this study, the influence of tumor biologic heterogeneity on the interaction between cytotoxic chemotherapy and...

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Detalles Bibliográficos
Autores principales: Rustum, Youcef M., Tóth, Károly, Seshadri, Mukund, Sen, Arindam, Durrani, Farukh A., Stott, Emily, Morrison, Carl D., Cao, Shousong, Bhattacharya, Arup
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860580/
https://www.ncbi.nlm.nih.gov/pubmed/20445750
http://dx.doi.org/10.1155/2010/396286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860580/
https://www.ncbi.nlm.nih.gov/pubmed/20445750
http://dx.doi.org/10.1155/2010/396286

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