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Allosteric mechanism of Ca(2+) activation and H(+)-inhibited gating of the MthK K(+) channel

MthK is a Ca(2+)-gated K(+) channel whose activity is inhibited by cytoplasmic H(+). To determine possible mechanisms underlying the channel’s proton sensitivity and the relation between H(+) inhibition and Ca(2+)-dependent gating, we recorded current through MthK channels incorporated into planar l...

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Detalles Bibliográficos
Autores principales: Pau, Victor P.T., Abarca-Heidemann, Karin, Rothberg, Brad S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860591/
https://www.ncbi.nlm.nih.gov/pubmed/20421375
http://dx.doi.org/10.1085/jgp.200910387

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