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Bioinformatic and experimental survey of 14-3-3-binding sites

More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3-3/phosphoprotein networks work. Mode I RXX(pS/pT)XP motifs dominate, although the +2 proline residue occurs in...

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Detalles Bibliográficos
Autores principales: Johnson, Catherine, Crowther, Sandra, Stafford, Margaret J., Campbell, David G., Toth, Rachel, MacKintosh, Carol
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860806/
https://www.ncbi.nlm.nih.gov/pubmed/20141511
http://dx.doi.org/10.1042/BJ20091834