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Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome

BACKGROUND: Development of the kidney is initiated when the ureteric bud (UB) branches from the Wolffian duct and invades the overlying metanephric mesenchyme (MM) triggering the mesenchymal/epithelial interactions that are the basis of organ formation. Multiple signaling pathways must be integrated...

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Detalles Bibliográficos
Autores principales: Karner, Courtney M., Dietrich, Martin F., Johnson, Eric B., Kappesser, Natalie, Tennert, Christian, Percin, Ferda, Wollnik, Bernd, Carroll, Thomas J., Herz, Joachim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861670/
https://www.ncbi.nlm.nih.gov/pubmed/20454682
http://dx.doi.org/10.1371/journal.pone.0010418