Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

The oncogenic PIM1 kinase has been implicated as a cofactor for c-MYC in prostate carcinogenesis. Here we show that in human prostate tumors, coexpression of c-MYC and PIM1 is associated with higher Gleason grades. Using a tissue recombination model coupled with lentiviral-mediated gene transfer we...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Kim, Jongchan, Roh, Meejeon, Franco, Omar E., Hayward, Simon W., Wills, Marcia L., Abdulkadir, Sarki A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861731/
https://www.ncbi.nlm.nih.gov/pubmed/20140016
http://dx.doi.org/10.1038/onc.2010.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861731/
https://www.ncbi.nlm.nih.gov/pubmed/20140016
http://dx.doi.org/10.1038/onc.2010.10

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