Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Oxidative stress results in apoptosis of neuronal cells, leading to neurodegenerative disorders. However, the underlying molecular mechanism remains to be elucidated. Here we show that hydrogen peroxide (H(2)O(2)), a major oxidant generated when oxidative stress occurs, induced apoptosis of neuronal...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Long, Xu, Baoshan, Liu, Lei, Luo, Yan, Yin, Jun, Zhou, Hongyu, Chen, Wenxing, Shen, Tao, Han, Xiuzhen, Huang, Shile
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861733/
https://www.ncbi.nlm.nih.gov/pubmed/20142804
http://dx.doi.org/10.1038/labinvest.2010.36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861733/
https://www.ncbi.nlm.nih.gov/pubmed/20142804
http://dx.doi.org/10.1038/labinvest.2010.36

Ejemplares similares