A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

We describe a new form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea (ENU)-induced mutation called elektra. Homozygotes showed enhanced susceptibility to bacterial and viral infections, and diminished numbers of T cells and inflammatory monocytes that failed to proliferate upon...

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Detalles Bibliográficos
Autores principales: Berger, Michael, Krebs, Philippe, Crozat, Karine, Li, Xiaohong, Croker, Ben A., Siggs, Owen M., Popkin, Daniel, Du, Xin, Lawson, Brian R., Theofilopoulos, Argyrios N., Xia, Yu, Khovananth, Kevin, Moresco, Eva Marie Y., Satoh, Takashi, Takeuchi, Osamu, Akira, Shizuo, Beutler, Bruce
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861894/
https://www.ncbi.nlm.nih.gov/pubmed/20190759
http://dx.doi.org/10.1038/ni.1847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861894/
https://www.ncbi.nlm.nih.gov/pubmed/20190759
http://dx.doi.org/10.1038/ni.1847

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