AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and NLRP3)-independent inflammasome 1, which activates caspase-1 leading to maturation of pro-interleukin-1β and inflammation. The nature of the cytoplasmic-DNA-sensing inflammas...

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Detalles Bibliográficos
Autores principales: Fernandes-Alnemri, Teresa, Yu, Je-Wook, Wu, Jianghong, Datta, Pinaki, Alnemri, Emad S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862225/
https://www.ncbi.nlm.nih.gov/pubmed/19158676
http://dx.doi.org/10.1038/nature07710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862225/
https://www.ncbi.nlm.nih.gov/pubmed/19158676
http://dx.doi.org/10.1038/nature07710

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