Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains

Experimental observation has led to the commonly held view that native state protein topology is the principle determinant of mechanical strength. However, the PKD domains of polycystin-1 challenge this assumption: they are stronger than predicted from their native structure. Molecular dynamics simu...

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Detalles Bibliográficos
Autores principales: Forman, Julia R., Yew, Zu Thur, Qamar, Seema, Sandford, Richard N., Paci, Emanuele, Clarke, Jane
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862302/
https://www.ncbi.nlm.nih.gov/pubmed/20004162
http://dx.doi.org/10.1016/j.str.2009.09.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862302/
https://www.ncbi.nlm.nih.gov/pubmed/20004162
http://dx.doi.org/10.1016/j.str.2009.09.013

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