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Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains
Experimental observation has led to the commonly held view that native state protein topology is the principle determinant of mechanical strength. However, the PKD domains of polycystin-1 challenge this assumption: they are stronger than predicted from their native structure. Molecular dynamics simu...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862302/ https://www.ncbi.nlm.nih.gov/pubmed/20004162 http://dx.doi.org/10.1016/j.str.2009.09.013 |