Cargando…

Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection

New strategies to self-assemble biocompatible materials into nanoscale, drug-loaded packages with improved therapeutic efficacy are needed for nanomedicine. To address this need, we developed artificial recombinant chimeric polypeptides (CPs) that spontaneously self-assemble into sub-100 nm size, ne...

Descripción completa

Detalles Bibliográficos
Autores principales: MacKay, J. Andrew, Chen, Mingnan, McDaniel, Jonathan R., Liu, Wenge, Simnick, Andrew J., Chilkoti, Ashutosh
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862348/
https://www.ncbi.nlm.nih.gov/pubmed/19898461
http://dx.doi.org/10.1038/nmat2569