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Towards reliable isoform quantification using RNA-SEQ data

BACKGROUND: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address the isoform quantification problem. Given a set of known splice variants, the goal is to estimate the relative abundance...

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Detalles Bibliográficos
Autores principales: Howard, Brian E, Heber, Steffen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863065/
https://www.ncbi.nlm.nih.gov/pubmed/20438653
http://dx.doi.org/10.1186/1471-2105-11-S3-S6