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Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery
BACKGROUND: With the classical, active-site oriented drug-development approach reaching its limits, protein ligand-binding sites in general and allosteric sites in particular are increasingly attracting the interest of medicinal chemists in the search for new types of targets and strategies to drug...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864279/ https://www.ncbi.nlm.nih.gov/pubmed/20356358 http://dx.doi.org/10.1186/1472-6807-10-9 |