A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization

Many mitosis inhibitors are powerful anticancer drugs. Tremendous efforts have been made to identify new anti-mitosis compounds for developing more effective and less toxic anti-cancer drugs. We have identified LJK-11, a synthetic analog of 5, 8-disubstituted quinazolines, as a novel mitotic blocker...

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Detalles Bibliográficos
Autores principales: Tian, Wei, Qin, Lili, Song, Qiaoling, He, Li, Ai, Midan, Jin, Yi, Zhou, Zuyu, You, Song, Long, Yaqiu, Yu, Qiang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864768/
https://www.ncbi.nlm.nih.gov/pubmed/20463925
http://dx.doi.org/10.1371/journal.pone.0010499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864768/
https://www.ncbi.nlm.nih.gov/pubmed/20463925
http://dx.doi.org/10.1371/journal.pone.0010499

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