Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8(+) T Cell Response

In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8(+) T cell immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals unable to produce Gal-9, because of gene knockout, develop acute and memory responses to HSV that are of greater magn...

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Detalles Bibliográficos
Autores principales: Sehrawat, Sharvan, Reddy, Pradeep B. J., Rajasagi, Naveen, Suryawanshi, Amol, Hirashima, Mitsuomi, Rouse, Barry T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865527/
https://www.ncbi.nlm.nih.gov/pubmed/20463811
http://dx.doi.org/10.1371/journal.ppat.1000882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865527/
https://www.ncbi.nlm.nih.gov/pubmed/20463811
http://dx.doi.org/10.1371/journal.ppat.1000882

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