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Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8(+) T Cell Response

In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8(+) T cell immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals unable to produce Gal-9, because of gene knockout, develop acute and memory responses to HSV that are of greater magn...

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Detalles Bibliográficos
Autores principales:	Sehrawat, Sharvan, Reddy, Pradeep B. J., Rajasagi, Naveen, Suryawanshi, Amol, Hirashima, Mitsuomi, Rouse, Barry T.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865527/ https://www.ncbi.nlm.nih.gov/pubmed/20463811 http://dx.doi.org/10.1371/journal.ppat.1000882

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