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Concomitant Duplications of Opioid Peptide and Receptor Genes before the Origin of Jawed Vertebrates

BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins, orphanin/nociceptin and beta-endorphin, respect...

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Detalles Bibliográficos
Autores principales: Sundström, Görel, Dreborg, Susanne, Larhammar, Dan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865548/
https://www.ncbi.nlm.nih.gov/pubmed/20463905
http://dx.doi.org/10.1371/journal.pone.0010512