Cargando…

Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions

After detection of a high prevalence of scrapie in a large dairy goat herd, 72 infected animals were examined by immunohistochemistry with prion protein (PrP) antibody Bar224 to study the pathogenesis of the infection. Tissues examined included the brain and thoracic spinal cord (TSC), a wide select...

Descripción completa

Detalles Bibliográficos
Autores principales:	González, Lorenzo, Martin, Stuart, Hawkins, Stephen A.C., Goldmann, Wilfred, Jeffrey, Martin, Sisó, Sílvia
Formato:	Texto
Lenguaje:	English
Publicado:	EDP Sciences 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865875/ https://www.ncbi.nlm.nih.gov/pubmed/20374697 http://dx.doi.org/10.1051/vetres/2010020

Ejemplares similares

Susceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources
por: González, Lorenzo, et al.
Publicado: (2012)

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie
por: Houston, Fiona, et al.
Publicado: (2015)

Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats
por: Sacchi, Paola, et al.
Publicado: (2018)

Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie
por: Dassanayake, Rohana P., et al.
Publicado: (2015)

Incidence of Infection in Prnp ARR/ARR Sheep following Experimental Inoculation with or Natural Exposure to Classical Scrapie
por: Jeffrey, Martin, et al.
Publicado: (2014)

Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats
por: Kim, Seon-Kwan, et al.
Publicado: (2019)

Polymorphisms of Codons 110, 146, 211 and 222 at the Goat PRNP Locus and Their Association with Scrapie in Greece
por: Gelasakis, Athanasios I., et al.
Publicado: (2021)

PRNP genetic variability and molecular typing of natural goat scrapie isolates in a high number of infected flocks
por: Fragkiadaki, Eirini G, et al.
Publicado: (2011)

Genetic profile of scrapie codons 146, 211 and 222 in the PRNP gene locus in three breeds of dairy goats
por: Vouraki, Sotiria, et al.
Publicado: (2018)

Monitoring of clinical signs in goats with transmissible spongiform encephalopathies
por: Konold, Timm, et al.
Publicado: (2010)

State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology
por: Vaccari, Gabriele, et al.
Publicado: (2009)

Evidence of scrapie transmission to sheep via goat milk
por: Konold, Timm, et al.
Publicado: (2016)

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom
por: Goldmann, Wilfred, et al.
Publicado: (2011)

Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
por: Kanata, Eirini, et al.
Publicado: (2014)

The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep
por: Simmons, Marion M, et al.
Publicado: (2010)

Low sequence diversity of the prion protein gene (PRNP) in wild deer and goat species from Spain
por: Pitarch, José Luis, et al.
Publicado: (2018)

Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds
por: Goldmann, W., et al.
Publicado: (2016)

The time-course of a scrapie outbreak
por: McIntyre, K Marie, et al.
Publicado: (2006)

Lack of Prion Accumulation in Lymphoid Tissues of PRNP ARQ/ARR Sheep Intracranially Inoculated with the Agent of Scrapie
por: Greenlee, Justin J., et al.
Publicado: (2014)

Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs
por: Vitale, Maria, et al.
Publicado: (2016)

Evidence in Sheep for Pre-Natal Transmission of Scrapie to Lambs from Infected Mothers
por: Foster, James D., et al.
Publicado: (2013)

Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie
por: Mammadova, Najiba, et al.
Publicado: (2020)

Goats naturally devoid of PrP(C) are resistant to scrapie
por: Salvesen, Øyvind, et al.
Publicado: (2020)

Correction: Evidence in Sheep for Pre-Natal Transmission of Scrapie to Lambs from Infected Mothers
por: Foster, James D., et al.
Publicado: (2014)

Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods
por: Langeveld, Jan P. M., et al.
Publicado: (2019)

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds
por: Teferedegn, Eden Yitna, et al.
Publicado: (2020)

BSE can propagate in sheep co-infected or pre-infected with scrapie
por: Chong, Angela, et al.
Publicado: (2021)

Epidemiological Characteristics of Classical Scrapie Outbreaks in 30 Sheep Flocks in the United Kingdom
por: McIntyre, K. Marie, et al.
Publicado: (2008)

The placenta shed from goats with classical scrapie is infectious to goat kids and lambs
por: Schneider, David A., et al.
Publicado: (2015)

Low-volume goat milk transmission of classical scrapie to lambs and goat kids
por: Madsen-Bouterse, Sally A., et al.
Publicado: (2018)

The Limits of Test-Based Scrapie Eradication Programs in Goats
por: Corbière, Fabien, et al.
Publicado: (2013)

First case of atypical scrapie in a goat in Japan
por: MATSUURA, Yuichi, et al.
Publicado: (2019)

Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrP(C)
por: Madsen-Bouterse, Sally A., et al.
Publicado: (2021)

Correction: Epidemiological Characteristics of Classical Scrapie Outbreaks in 30 Sheep Flocks in the United Kingdom
por: McIntyre, K. Marie, et al.
Publicado: (2009)

Sparse PrP(Sc )accumulation in the placentas of goats with naturally acquired scrapie
por: O'Rourke, Katherine I, et al.
Publicado: (2011)

Genetic Variation in the Prion Protein Gene (PRNP) of Two Tunisian Goat Populations
por: Kdidi, Samia, et al.
Publicado: (2021)

Genotyping and surveillance for scrapie in Finnish sheep
por: Hautaniemi, Maria, et al.
Publicado: (2012)

Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases
por: Acín, Cristina, et al.
Publicado: (2021)

PRNP Polymorphisms in Eight Local Goat Populations/Breeds from Central and Southern Italy
por: Torricelli, Martina, et al.
Publicado: (2021)

Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe
por: Robinson, Amy L., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_829jd730iqhpe38isus7hohms0