Active site remodeling accompanies thioester bond formation in the SUMO E1

E1 enzymes activate ubiquitin (Ub) and ubiquitin-like (Ubl) proteins in two steps by carboxy-terminal adenylation and thioester bond formation to a conserved catalytic cysteine in the E1 Cys domain. The structural basis for these intermediates remains unknown. Here we report crystal structures for h...

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Detalles Bibliográficos
Autores principales: Olsen, Shaun K., Capili, Allan D., Lu, Xuequan, Tan, Derek S., Lima, Christopher D.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866016/
https://www.ncbi.nlm.nih.gov/pubmed/20164921
http://dx.doi.org/10.1038/nature08765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866016/
https://www.ncbi.nlm.nih.gov/pubmed/20164921
http://dx.doi.org/10.1038/nature08765

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