Transcription-Associated Mutagenesis Increases Protein Sequence Diversity More Effectively than Does Random Mutagenesis in Escherichia coli

BACKGROUND: During transcription, the nontranscribed DNA strand becomes single-stranded DNA (ssDNA), which can form secondary structures. Unpaired bases in the ssDNA are less protected from mutagens and hence experience more mutations than do paired bases. These mutations are called transcription-as...

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Detalles Bibliográficos
Autores principales: Kim, Hyunchul, Lee, Baek-Seok, Tomita, Masaru, Kanai, Akio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866735/
https://www.ncbi.nlm.nih.gov/pubmed/20479947
http://dx.doi.org/10.1371/journal.pone.0010567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866735/
https://www.ncbi.nlm.nih.gov/pubmed/20479947
http://dx.doi.org/10.1371/journal.pone.0010567

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