Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

Signaling and repair of DNA double-strand breaks (DSBs) are critical for preventing immunodeficiency and cancer. These DNA breaks result from exogenous and endogenous DNA insults but are also programmed to occur during physiological processes such as meiosis and immunoglobulin heavy chain (IgH) clas...

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Detalles Bibliográficos
Autores principales: Li, Li, Halaby, Marie-Jo, Hakem, Anne, Cardoso, Renato, El Ghamrasni, Samah, Harding, Shane, Chan, Norman, Bristow, Robert, Sanchez, Otto, Durocher, Daniel, Hakem, Razqallah
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867283/
https://www.ncbi.nlm.nih.gov/pubmed/20385750
http://dx.doi.org/10.1084/jem.20092437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867283/
https://www.ncbi.nlm.nih.gov/pubmed/20385750
http://dx.doi.org/10.1084/jem.20092437

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