Co-receptor choice by Vα14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection

Mouse natural killer T (NKT) cells with an invariant Vα14-Jα18 rearrangement (Vα14 invariant [Vα14i] NKT cells) are either CD4(+)CD8(−) or CD4(−)CD8(−). Because transgenic mice with forced CD8 expression in all T cells exhibited a profound NKT cell deficit, the absence of CD8 has been attributed to...

Descripción completa

Detalles Bibliográficos
Autores principales: Engel, Isaac, Hammond, Kirsten, Sullivan, Barbara A., He, Xi, Taniuchi, Ichiro, Kappes, Dietmar, Kronenberg, Mitchell
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867285/
https://www.ncbi.nlm.nih.gov/pubmed/20404101
http://dx.doi.org/10.1084/jem.20090557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867285/
https://www.ncbi.nlm.nih.gov/pubmed/20404101
http://dx.doi.org/10.1084/jem.20090557

Ejemplares similares