Hidden reach of the micromanagers

Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens. Se...

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Detalles Bibliográficos
Autores principales: Linsley, Peter S, Jackson, Aimee L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867781/
https://www.ncbi.nlm.nih.gov/pubmed/20529236
http://dx.doi.org/10.1186/1741-7007-8-53
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author Linsley, Peter S
Jackson, Aimee L
author_facet Linsley, Peter S
Jackson, Aimee L
author_sort Linsley, Peter S
collection PubMed
description Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens. See research article http://www.biomedcentral.com/1471-2164/11/175
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spelling pubmed-28677812010-05-12 Hidden reach of the micromanagers Linsley, Peter S Jackson, Aimee L BMC Biol Commentary Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens. See research article http://www.biomedcentral.com/1471-2164/11/175 BioMed Central 2010-05-11 /pmc/articles/PMC2867781/ /pubmed/20529236 http://dx.doi.org/10.1186/1741-7007-8-53 Text en Copyright ©2010 Linsley and Jackson; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Linsley, Peter S
Jackson, Aimee L
Hidden reach of the micromanagers
title Hidden reach of the micromanagers
title_full Hidden reach of the micromanagers
title_fullStr Hidden reach of the micromanagers
title_full_unstemmed Hidden reach of the micromanagers
title_short Hidden reach of the micromanagers
title_sort hidden reach of the micromanagers
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867781/
https://www.ncbi.nlm.nih.gov/pubmed/20529236
http://dx.doi.org/10.1186/1741-7007-8-53
work_keys_str_mv AT linsleypeters hiddenreachofthemicromanagers
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