Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

BACKGROUND: New drug targets are urgently needed for parasites of socio-economic importance. Genes that are essential for parasite survival are highly desirable targets, but information on these genes is lacking, as gene knockouts or knockdowns are difficult to perform in many species of parasites....

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Detalles Bibliográficos
Autores principales: Doyle, Maria A, Gasser, Robin B, Woodcroft, Ben J, Hall, Ross S, Ralph, Stuart A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867826/
https://www.ncbi.nlm.nih.gov/pubmed/20361874
http://dx.doi.org/10.1186/1471-2164-11-222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867826/
https://www.ncbi.nlm.nih.gov/pubmed/20361874
http://dx.doi.org/10.1186/1471-2164-11-222

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