Loss of phosphoinositide 3-kinase γ decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis

BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) has been depicted as a major regulator of inflammatory processes, including leukocyte activation and migration towards several chemokines. This study aims to explore the role of PI3Kγ in the murine model of antigen-induced arthritis (AIA). METHODS: Dev...

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Detalles Bibliográficos
Autores principales: Gruen, Michael, Rose, Christina, König, Christian, Gajda, Mieczyslaw, Wetzker, Reinhard, Bräuer, Rolf
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867834/
https://www.ncbi.nlm.nih.gov/pubmed/20374644
http://dx.doi.org/10.1186/1471-2474-11-63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867834/
https://www.ncbi.nlm.nih.gov/pubmed/20374644
http://dx.doi.org/10.1186/1471-2474-11-63

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