Cargando…
Computational Identification of Uncharacterized Cruzain Binding Sites
Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, claims 50,000 lives annually and is the leading cause of infectious myocarditis in the world. As current antichagastic therapies like nifurtimox and benznidazole are highly toxic, ineffective at parasite eradication, and subject t...
Autores principales: | Durrant, Jacob D., Keränen, Henrik, Wilson, Benjamin A., McCammon, J. Andrew |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867933/ https://www.ncbi.nlm.nih.gov/pubmed/20485483 http://dx.doi.org/10.1371/journal.pntd.0000676 |
Ejemplares similares
-
Novel Cruzain Inhibitors for the Treatment of Chagas’ Disease
por: Rogers, Kathleen E, et al.
Publicado: (2012) -
Computer-Aided Identification of Trypanosoma brucei Uridine Diphosphate Galactose 4′-Epimerase Inhibitors: Toward the Development of Novel Therapies for African Sleeping Sickness
por: Durrant, Jacob D., et al.
Publicado: (2010) -
NNScore: A Neural-Network-Based Scoring Function for the Characterization of Protein−Ligand Complexes
por: Durrant, Jacob D., et al.
Publicado: (2010) -
AutoClickChem: Click Chemistry in Silico
por: Durrant, Jacob D., et al.
Publicado: (2012) -
Molecular dynamics simulations and drug discovery
por: Durrant, Jacob D, et al.
Publicado: (2011)