Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: Oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder

The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder (PTSD). On Day 1, sixteen wildtype (WT) and sixteen ppENK male mice were given a 3 mA or no...

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Detalles Bibliográficos
Autores principales: Kung, Jen-Chuang, Chen, Tsung-Chieh, Shyu, Bai-Chuang, Hsiao, Sigmund, Huang, Andrew Chih Wei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867948/
https://www.ncbi.nlm.nih.gov/pubmed/20406487
http://dx.doi.org/10.1186/1423-0127-17-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867948/
https://www.ncbi.nlm.nih.gov/pubmed/20406487
http://dx.doi.org/10.1186/1423-0127-17-29

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