A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction

BACKGROUND: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propose a general knowledge-guided scoring (KGS) strategy to tackle this problem. Our KGS strategy computes the binding consta...

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Detalles Bibliográficos
Autores principales: Cheng, Tiejun, Liu, Zhihai, Wang, Renxiao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Methodology article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868011/
https://www.ncbi.nlm.nih.gov/pubmed/20398404
http://dx.doi.org/10.1186/1471-2105-11-193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868011/
https://www.ncbi.nlm.nih.gov/pubmed/20398404
http://dx.doi.org/10.1186/1471-2105-11-193

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