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Synthetic partial agonists reveal key steps in IP(3) receptor activation
Inositol 1,4,5-trisphosphate receptors (IP(3)R) are ubiquitous intracellular Ca(2+) channels. IP(3)binding to the IP(3)-binding core (IBC) near the N-terminal initiates conformational changes that lead to opening of a pore. The mechanisms are unresolved. We synthesized 2-O-modified IP(3) analogues t...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869033/ https://www.ncbi.nlm.nih.gov/pubmed/19668195 http://dx.doi.org/10.1038/nchembio.195 |