Cargando…

H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype

BACKGROUND: About 1–5% of cancer patients suffer from significant normal tissue reactions as a result of radiotherapy (RT). It is not possible at this time to predict how most patients’ normal tissues will respond to RT. DNA repair dysfunction is implicated in sensitivity to RT particularly in genes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasireddy, R S, Sprung, C N, Cempaka, N L, Chao, M, McKay, M J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869166/ https://www.ncbi.nlm.nih.gov/pubmed/20461094 http://dx.doi.org/10.1038/sj.bjc.6605666

Ejemplares similares

ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels
por: Rondeau, S, et al.
Publicado: (2015)

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
por: Jakob, Burkhard, et al.
Publicado: (2011)

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy
por: Mladenov, Emil, et al.
Publicado: (2013)

Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair
por: Tanikawa, M, et al.
Publicado: (2013)

Role of Elg1 protein in double strand break repair
por: Ogiwara, Hideaki, et al.
Publicado: (2007)

Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks
por: Martin, N T, et al.
Publicado: (2014)

H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues
por: Firsanov, Denis V., et al.
Publicado: (2011)

Phosphorylation: The Molecular Switch of Double-Strand Break Repair
por: Summers, K. C., et al.
Publicado: (2011)

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase
por: Hiyoshi, H, et al.
Publicado: (2012)

Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks
por: Rybak, Paulina, et al.
Publicado: (2016)

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
por: Vítor, Alexandra C., et al.
Publicado: (2020)

The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
por: Jimeno, Sonia, et al.
Publicado: (2021)

DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
por: Collins, Patrick L., et al.
Publicado: (2020)

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks
por: Mah, Li-Jeen, et al.
Publicado: (2011)

Ctf18 is required for homologous recombination-mediated double-strand break repair
por: Ogiwara, Hideaki, et al.
Publicado: (2007)

Epigenetic Mechanisms in DNA Double Strand Break Repair: A Clinical Review
por: Fernandez, Alejandra, et al.
Publicado: (2021)

Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks
por: El-Awady, R A, et al.
Publicado: (2003)

Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity
por: Oeck, S., et al.
Publicado: (2017)

The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer
por: Pattje, W J, et al.
Publicado: (2010)

Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma
por: Birgersdotter, A, et al.
Publicado: (2009)

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes
por: Glover, Lucy, et al.
Publicado: (2008)

ZEB1 promotes non-homologous end joining double-strand break repair
por: Genetta, Thomas L, et al.
Publicado: (2023)

Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
por: Cortés-Ledesma, Felipe, et al.
Publicado: (2007)

G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring
por: Curwen, G B, et al.
Publicado: (2005)

Flow cytometric assessment of DNA double-strand break and repair kinetics in prediction of intrinsic radiosensitivity
por: Bahreyni-Toossi, Mohammad-Taghi, et al.
Publicado: (2022)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas
por: Kopantzev, E P, et al.
Publicado: (2010)

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition
por: Krubasik, D, et al.
Publicado: (2006)

“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process
por: Serrano-Benítez, Almudena, et al.
Publicado: (2020)

DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4
por: Lees-Miller, Susan P.
Publicado: (2014)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

FADD phosphorylation is critical for cell cycle regulation in breast cancer cells
por: Matsuyoshi, S, et al.
Publicado: (2006)

γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
por: Kinner, Andrea, et al.
Publicado: (2008)

Capture of linear fragments at a double-strand break in yeast
por: Haviv-Chesner, Anat, et al.
Publicado: (2007)

Regulation of DNA Double Strand Breaks Processing: Focus on Barriers
por: Marini, Federica, et al.
Publicado: (2019)

Involvement of DNA polymerase μ in the repair of a specific subset of DNA double-strand breaks in mammalian cells
por: Capp, Jean-Pascal, et al.
Publicado: (2007)

Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus
por: Namas, Rajaie, et al.
Publicado: (2016)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma
por: Lau, Y S, et al.
Publicado: (2007)

LINE-1 methylation status of endogenous DNA double-strand breaks
por: Pornthanakasem, Wichai, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_6k3agmoftchq8h4vtv6e0eqppp