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Superoxide Dismutase 1 and tgSOD1(G93A) Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that specifically affects motor neurons and leads to a progressive and ultimately fatal loss of function, resulting in death typically within 3 to 5 years of diagnosis. The disease starts with a focal centre of weakness,...
Autores principales: | Chia, Ruth, Tattum, M. Howard, Jones, Samantha, Collinge, John, Fisher, Elizabeth M. C., Jackson, Graham S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869360/ https://www.ncbi.nlm.nih.gov/pubmed/20498711 http://dx.doi.org/10.1371/journal.pone.0010627 |
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