Engineering Cofactor Preference of Ketone Reducing Biocatalysts: A Mutagenesis Study on a γ-Diketone Reductase from the Yeast Saccharomyces cerevisiae Serving as an Example

The synthesis of pharmaceuticals and catalysts more and more relies on enantiopure chiral building blocks. These can be produced in an environmentally benign and efficient way via bioreduction of prochiral ketones catalyzed by dehydrogenases. A productive source of these biocatalysts is the yeast Sa...

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Detalles Bibliográficos
Autores principales: Katzberg, Michael, Skorupa-Parachin, Nàdia, Gorwa-Grauslund, Marie-Françoise, Bertau, Martin
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871135/
https://www.ncbi.nlm.nih.gov/pubmed/20480039
http://dx.doi.org/10.3390/ijms11041735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871135/
https://www.ncbi.nlm.nih.gov/pubmed/20480039
http://dx.doi.org/10.3390/ijms11041735

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