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In Planta Protein Sialylation through Overexpression of the Respective Mammalian Pathway
Many therapeutic proteins are glycosylated and require terminal sialylation to attain full biological activity. Current manufacturing methods based on mammalian cell culture allow only limited control of this important posttranslational modification, which may lead to the generation of products with...
Autores principales: | Castilho, Alexandra, Strasser, Richard, Stadlmann, Johannes, Grass, Josephine, Jez, Jakub, Gattinger, Pia, Kunert, Renate, Quendler, Heribert, Pabst, Martin, Leonard, Renaud, Altmann, Friedrich, Steinkellner, Herta |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871460/ https://www.ncbi.nlm.nih.gov/pubmed/20305285 http://dx.doi.org/10.1074/jbc.M109.088401 |
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