Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY

Human choline kinase (ChoK) catalyzes the first reaction in phosphatidylcholine biosynthesis and exists as ChoKα (α1 and α2) and ChoKβ isoforms. Recent studies suggest that ChoK is implicated in tumorigenesis and emerging as an attractive target for anticancer chemotherapy. To extend our understandi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Bum Soo, Allali-Hassani, Abdellah, Tempel, Wolfram, Finerty, Patrick J., MacKenzie, Farrell, Dimov, Svetoslav, Vedadi, Masoud, Park, Hee-Won
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871500/
https://www.ncbi.nlm.nih.gov/pubmed/20299452
http://dx.doi.org/10.1074/jbc.M109.039024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871500/
https://www.ncbi.nlm.nih.gov/pubmed/20299452
http://dx.doi.org/10.1074/jbc.M109.039024

Ejemplares similares