A homozygous frameshift mutation in the murine filaggrin gene facilitates enhanced percutaneous allergen priming

Loss-of-function mutations in the filaggrin gene (FLG), cause the semi-dominant keratinizing disorder, ichthyosis vulgaris1, and convey major genetic risk to atopic dermatitis/eczema, eczema-associated asthma2,3 and other allergic phenotypes5. Several low frequency FLG null alleles occur in European...

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Detalles Bibliográficos
Autores principales: Fallon, Padraic G., Sasaki, Takashi, Sandilands, Aileen, Campbell, Linda E., Saunders, Sean P., Mangan, Niamh E., Callanan, John J., Kawasaki, Hiroshi, Shiohama, Aiko, Kubo, Akiharu, Sundberg, John, Presland, Richard B., Fleckman, Philip, Shimizu, Nobuyoshi, Kudoh, Jun, Irvine, Alan D., Amagai, Masayuki, McLean, W. H. Irwin
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872154/
https://www.ncbi.nlm.nih.gov/pubmed/19349982
http://dx.doi.org/10.1038/ng.358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872154/
https://www.ncbi.nlm.nih.gov/pubmed/19349982
http://dx.doi.org/10.1038/ng.358

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