Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging

A central goal of biogerontology is to identify robust gene-expression biomarkers of aging. Here we develop a method where the biomarkers are networks of genes selected based on age-dependent activity and a graph-theoretic property called modularity. Tested on Caenorhabditis elegans, our algorithm y...

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Detalles Bibliográficos
Autores principales: Fortney, Kristen, Kotlyar, Max, Jurisica, Igor
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872873/
https://www.ncbi.nlm.nih.gov/pubmed/20128910
http://dx.doi.org/10.1186/gb-2010-11-2-r13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872873/
https://www.ncbi.nlm.nih.gov/pubmed/20128910
http://dx.doi.org/10.1186/gb-2010-11-2-r13

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