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Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging
A central goal of biogerontology is to identify robust gene-expression biomarkers of aging. Here we develop a method where the biomarkers are networks of genes selected based on age-dependent activity and a graph-theoretic property called modularity. Tested on Caenorhabditis elegans, our algorithm y...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872873/ https://www.ncbi.nlm.nih.gov/pubmed/20128910 http://dx.doi.org/10.1186/gb-2010-11-2-r13 |