Endoplasmic Reticulum Ca(2+) Increases Enhance Mutant Glucocerebrosidase Proteostasis

Altering intracellular calcium levels is known to partially restore mutant enzyme homeostasis in several lysosomal storage diseases, but why? We hypothesize that endoplasmic reticulum (ER) calcium level increases enhance the folding, trafficking and function of these mutant misfolding/degradation-pr...

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Detalles Bibliográficos
Autores principales: Ong, Derrick Sek Tong, Mu, Ting-Wei, Palmer, Amy E., Kelly, Jeffery W.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873071/
https://www.ncbi.nlm.nih.gov/pubmed/20453863
http://dx.doi.org/10.1038/nchembio.368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873071/
https://www.ncbi.nlm.nih.gov/pubmed/20453863
http://dx.doi.org/10.1038/nchembio.368

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