Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice

BACKGROUND: Topors is a nuclear protein that co-localizes with promyelocytic leukemia bodies and has both ubiquitin and SUMO E3 ligase activity. Expression studies implicated Topors as a tumor suppressor in various malignancies. To gain insight into the function of Topors, we generated a Topors-defi...

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Detalles Bibliográficos
Autores principales: Marshall, Henderson, Bhaumik, Mantu, Aviv, Hana, Moore, Dirk, Yao, Ming, Dutta, Jayeeta, Rahim, Hussein, Gounder, Murugesan, Ganesan, Shridar, Saleem, Ahamed, Rubin, Eric
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873312/
https://www.ncbi.nlm.nih.gov/pubmed/20429939
http://dx.doi.org/10.1186/1471-2199-11-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873312/
https://www.ncbi.nlm.nih.gov/pubmed/20429939
http://dx.doi.org/10.1186/1471-2199-11-31

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