Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

BACKGROUND: Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist antibodies, termed Tri-mAb, consisting of anti-DR5, anti-CD40 and anti-CD137 has...

Descripción completa

Detalles Bibliográficos
Autores principales: Westwood, Jennifer A, Darcy, Phillip K, Guru, Preethi Mayura, Sharkey, Janelle, Pegram, Hollie J, Amos, Sally M, Smyth, Mark J, Kershaw, Michael H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873376/
https://www.ncbi.nlm.nih.gov/pubmed/20426873
http://dx.doi.org/10.1186/1479-5876-8-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873376/
https://www.ncbi.nlm.nih.gov/pubmed/20426873
http://dx.doi.org/10.1186/1479-5876-8-42

Ejemplares similares